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New AI-Guided blood test could slash unnecessary antibiotic use

NCT ID NCT07205575

Diagnosis Sponsor: Qilu Hospital of Shandong University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a blood test that measures three proteins (ICAM1, CFHR5, and GRN) to help doctors quickly tell whether a fever is caused by bacteria or a virus. Researchers studied 394 adults with high fever and short illness duration. The goal is to improve diagnosis and reduce unnecessary antibiotic prescriptions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Proteomic Biomarker Panel (blood test measuring ICAM1, CFHR5, and GRN proteins)
What this could lead to
If successful, this blood test could help doctors quickly tell whether a fever is caused by bacteria or a virus, reducing unnecessary antibiotic use.
What could go wrong
This is a completed diagnostic study, not a treatment trial. The test's accuracy may not be high enough for routine use, and results may not apply to all patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

394 people

The number who actually took part.

Started

Sep 2021

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients aged 14 years or older who presented to the emergency department with acute febrile illness (fever ≤14 days, ≥38°C within 72 hours) and suspected bacterial or viral infection.

Ages

14 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥14 years； * Body temperature \> 38°C(within the past 72 hours)； * Disease duration ≤ 14 days； * Provision of informed consent by patient or legal guardian. Exclusion Criteria: * Underlying diseases affecting immune function (e.g., advanced malignancy, autoimmune disease, immunodeficiency, use of immunosuppressants); * Pregnancy; * Mixed infections (including viral-bacterial co-infections, bacterial or viral-fungal co-infections, or autoimmune disease concomitant with bacterial infection); * indeterminate or negative microbiological testing ; * inability to provide informed consent

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Conditions

The condition(s) this trial relates to.

bacterial infectious disease infectious disease with sepsis Sepsis viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute febrile illness Bacterial infections Sepsis Viral infections

Contacts and locations

Locations

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012, China

More trials for these conditions

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