Could a 24-Hour liquid diet make GLP-1 users safer for surgery?
NCT ID NCT06839248
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether a 24-hour clear liquid diet reduces leftover stomach contents in people taking weekly GLP-1 medications (like Ozempic). These drugs can slow digestion, raising the risk of stomach contents entering the lungs during procedures. Researchers will compare the liquid diet to standard fasting rules in 154 adults using a stomach ultrasound to check results.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- 24-hour clear liquid diet
- What this could lead to
- If successful, this could lead to better fasting guidelines for patients on GLP-1 medications, reducing the risk of stomach contents entering the lungs during surgery.
- What could go wrong
- This is a small, early-stage trial (154 participants) testing a dietary change, not a new drug. Results may not apply to all patients or settings, and the intervention may be hard to follow.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 154 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2025
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years old at enrolment. * Have regularly administered any type of once-weekly GLP-1 RA medication for a period of at least one month prior to randomisation. * If allocated to follow standard fasting guidelines, willing to adhere to ASA and ANZCA preoperative fasting requirements. This requires participants to only consume clear liquids up to 2 hours, a light or low calorific meal up to 6 hours, and fasting from fried foods, fatty foods, or meat for at least 8 hours prior to the trial visit. * If allocated to follow a 24-hour clear liquid diet, willing to adhere to nothing-by-mouth (NPO) for solids and last intake of clear liquids no less than 2 hours prior to the trial visit. * Provide a signed and dated informed consent form for study participation in line with the requirements of the human research ethics committee (HREC) of the study site. Exclusion Criteria: Participants meeting any of the following criteria, indicative of abnormal anatomy and not validated by gastric ultrasound, will be excluded from this trial: * Has a recent history of gastrointestinal bleed within the previous 1 month from enrolment. * Has a history of previous lower oesophageal or gastric surgery. * Has a known abnormal upper gastrointestinal anatomy, including hiatus hernia or gastric tumours. In addition, participants meeting any the of following criteria will be excluded from this trial: * Participant reports having been previously diagnosed with a clinically significant gastric emptying abnormality such as gastroparesis. * Participant reports concomitant use of insulin. * Unable to assume the right lateral decubitus position required for gastric ultrasound assessment. * Participant has difficulty fully understanding PICF or study materials due to a primary language other than English.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Melbourne Gastro Oesophageal Surgery (MGOS)
RECRUITINGMelbourne, Victoria, 3002, Australia
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St Vincent's Hospital Melbourne
RECRUITINGMelbourne, Victoria, 3065, Australia
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