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Eye tissue thickness measured in macular disease patients and healthy adults

NCT ID NCT06723288

Knowledge-focused Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study measured the thickness of the conjunctiva and Tenon's capsule (outer eye layers) in 736 people with neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME), and in healthy volunteers of similar age. Researchers used a special eye scanner (SD-OCT) to take these measurements. No treatment was given; the goal was to collect data that may help doctors better understand eye anatomy in these conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

736 people

The number who actually took part.

Started

Dec 2024

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with nAMD or DME and age-matched healthy subjects from the general population.

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For nAMD/DME participants: \- Diagnosis of nAMD/DME For healthy subjects: \- Normal visual function Exclusion Criteria: * Current or past treatment for glaucoma (only for healthy subjects) * Dry eye disease except those treated only with artificial tears * Ocular hypertension treated with hypotensive drugs * Pterygium * Strabismus * Previous ocular surgery except cataract surgery * Cataract surgery with scleral incision * Current contact lens wearers * Myopia with more than 6 diopters * Corneal transplant * History of ocular surface inflammation * Active or recent conjunctivitis infection * Pregnancy * Participant who has already received an IVT injection in the superotemporal quadrant (only for nAMD/DME participants)

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Conditions

The condition(s) this trial relates to.

diabetic macular edema wet macular degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetic macular edema Neovascular age-related macular degeneration

Contacts and locations

Locations

  • Centro de Oftalmologia Barraquer

    Barcelona, 08021, Spain

  • Clinica Baviera

    Madrid, 28046, Spain

  • Clinica Oftalmologica Aiken

    Valencia, 46004, Spain

  • Clinica Universitaria de Navarra

    Pamplona, Navarre, 31008, Spain

  • Hospital Arnau de Vilanova (Valencia)

    Valencia, 46015, Spain

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Clínic i Provincial de Barcelona

    Barcelona, 08036, Spain

  • Hospital General de Catalunya

    San Cugat Del Valles, Barcelona, 08195, Spain

  • Hospital Universitario Fundacion Jimenez Diaz.

    Madrid, 28040, Spain

  • Hospital Universitario La Paz

    Madrid, 28046, Spain

  • Hospital Universitario Puerta de Hierro

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Rio Hortega

    Valladolid, 47012, Spain

  • Hospital Universitario Vall d Hebron

    Barcelona, 08035, Spain

  • Hospital Universitario Virgen de la Macarena

    Seville, 41007, Spain

  • Hospital Universitario de Bellvitge

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Hospital Virgen del Rocio

    Seville, 41013, Spain

  • Hospital de la Arruzafa. Servicio de Oftalmologia

    Córdoba, 14012, Spain

  • Institut de la Macula i la retina

    Barcelona, 08022, Spain

  • Instituto Oftalmologico Fernandez Vega

    Oviedo, Principality of Asturias, 33012, Spain

  • Oftalvist Valencia

    Burjassot, Valencia, 46100, Spain

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