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New nerve block could make hernia surgery less stressful

NCT ID NCT07324863

Symptom relief Sponsor: Tanta University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a special nerve block, called EXORA, can reduce the body's stress response and pain during umbilical hernia surgery. One hundred adults will be randomly assigned to receive either general anesthesia alone or general anesthesia plus the EXORA block. Researchers will measure blood sugar and cortisol levels as stress indicators, and track how much pain medication patients need after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine
What this could lead to
If it works, this could lead to a better way to manage pain and stress during hernia surgery, potentially reducing the need for strong painkillers.
What could go wrong
This is a small, early-stage trial. The nerve block may not provide significant benefit over standard anesthesia, and there are always risks like allergic reactions or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged from 21 to 65 years. * Both sexes. * American Society of Anesthesiologists (ASA) Physical status I and Ⅱ. * Schedule for elective umbilical hernia surgery under general anesthesia. Exclusion Criteria: * ASA Ⅲ or Ⅳ. * Patients with metabolic abnormalities, e.g., diabetes mellitus. * Patients receiving corticosteroids. * History of allergies to local anesthetics. * Bleeding or coagulation disorders. * Anatomical abnormalities. * Psychiatric and neurological disorders. * Complicated hernial defect (obstructed). * Patient refusal.

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Conditions

The condition(s) this trial relates to.

Hernia, Umbilical

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

External oblique Neuroendocrine stress response Rectus abdominis plane block Ultrasound Umbilical hernia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Tanta University

    RECRUITING

    Tanta, 31527, Egypt

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