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Baking soda and bike rides: a new hope for kidney Patients' fatigue?

NCT ID NCT05928936

Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether taking sodium bicarbonate pills and doing regular stationary bike exercise can improve exercise capacity in people with chronic kidney disease (CKD). Researchers will enroll 156 adults with CKD, kidney transplant recipients, or healthy controls. Participants will take sodium bicarbonate twice daily and exercise three times a week for 12 weeks. The main goal is to see if these interventions increase the amount of oxygen the body can use during exercise (VO2 peak).

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Sodium bicarbonate (taken as a pill) and supervised exercise training on a stationary bike
What this could lead to
If it works, this could point toward a simple, low-cost way to help people with chronic kidney disease feel less tired and be more active.
What could go wrong
This is a mid-stage trial with only 156 participants, so results may not apply to everyone. The sodium bicarbonate dose may need frequent adjustment to avoid side effects like metabolic alkalosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 156 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2022

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients with CKD (Stages III and IV), kidney transplant recipients with varying degrees of kidney function, or persons without kidney disease as matched study controls * sedentary and do not regularly exercise (defined as exercising \< 20 minutes twice per week) * CKD patients must have stable renal function (no greater than a decline of estimated glomerular filtration (eGFR) of 1 cc/min/1.73 m2 per month over the prior 6 months) and baseline serum bicarbonate 22-24 mmol/L * comorbid hypertension Exclusion Criteria: * severe CKD (eGFR\<15 cc/min) * metabolic alkalosis * current treatment with bicarbonate * ongoing drug or alcohol abuse * diabetic neuropathy, autonomic dysfunction * any serious disease that might influence survival * anemia with hemoglobin \<10 g/dL * clinical evidence of heart failure * volume overload or ejection fraction below 45% * symptomatic heart disease by EKG, stress test, and/or history * treatment with central α-agonists (clonidine) * myocardial infarction or cerebrovascular accident within the past six months * uncontrolled hypertension (BP\>170/100 mm Hg) * low BP\<100/50 mm Hg * surgery within the past 3 months * pregnancy or plans to become pregnant * inability to exercise on a stationary bicycle * contraindication to temporary withdrawal of α- and β-blockers * peripheral arterial disease * class 3 obesity (BMI\>40) * hypo- or hyperkalemia (K\<3.5meq/L, K\>5.0 meq/L) * current use of immunosuppressive medications (including but not limited to steroids, cyclophosphamide, calcineurin inhibitors, mycophenolate, biologics, methotrexate, etc) * arteriovenous (AV) fistula/graft * any contraindication to MR scanning including cardiac pacemaker, cochlear implants, neurostimulators, implanted devices with metal, any metal in the body that could pose a hazard during scanning, history of claustrophobia

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Atlanta VA Medical Center

    RECRUITING

    Decatur, Georgia, 30033, United States

  • Emory Clinic

    RECRUITING

    Atlanta, Georgia, 30322, United States

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