Exercise may shield Women's bones and joints after menopause
NCT ID NCT05889598
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a supervised resistance exercise program can reduce the risk of osteoporosis and osteoarthritis in women aged 50-70 who have gone through menopause. Participants will do leg and core exercises twice a week for 30-40 minutes. Researchers will measure changes in bone density, cartilage, and muscle size to see if the program helps prevent these common age-related conditions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- resistance exercise programme
- What this could lead to
- If successful, this could show that specific exercises help prevent bone and joint diseases in postmenopausal women.
- What could go wrong
- This is a small, early-stage study with no blinding, so results may not be conclusive or apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 110 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2022
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 70 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women between 50-70 years; * Experienced last menstrual cycle, hormonal contraception or menopausal hormone replacement therapy at least five years ago; * Independent living and able to come into the university; * Healthy women: not previously diagnosed with osteoporosis or knee osteoarthritis, other major medical conditions; * Able to understand English. Exclusion Criteria: * Any existing symptomatic knee, hip, back injury or any medical conditions or injuries which would affect the ability or safety to perform exercise or influence bone/cartilage, including unstable angina, uncontrolled hypertension, a history of heart failure, and a history of cardiovascular disease and conditions; * Taking medication affecting bone/cartilage metabolism; * Regular (\>once per week on average) participation in resistance training with loading greater than bodyweight or in high impact (impact greater than jogging); * Blood pressure exceeding 150/90 mmHg; * BMI \> 30 kg/m2; * Contraindications to MRI or DXA (e.g. Metallic implants); * Osteoporotic (FRAX score according to which the participant would be advised to seek treatment); * Fracture within the past year.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Loughborough University
Loughborough, Leicestershire, LE11 3TU, United Kingdom
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