Can exercise MRI reveal safe activity levels for aneurysm patients?
NCT ID NCT06789809
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study uses exercise MRI to see how the aorta behaves during exercise in people with aortic aneurysm. Researchers will compare these images with tissue samples from surgery. The goal is to help doctors and patients understand safe exercise limits. The study enrolls 35 participants, including healthy controls and aneurysm patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors and patients know safe exercise levels for people with aortic aneurysm.
- What could go wrong
- This is a small, early observational study (35 people) that measures tissue properties, not a treatment. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 35 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2023
- Expected to finish
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Mar 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy controls for baseline comparison 1. Must be 18 years or older 2. No history of cardiovascular disease, neither hypertension, diabetes nor hypercholesterolemia 2. Aneurysm patients who have not yet been operated on but are currently being monitored 1. Must be 18 years or older 2. No history of operation for aortic aneurysm 3. Pre-operative aneurysm patients: imaged pre-operatively and 12 months 1. Patients admitted at the CCF cardiothoracic services for elective surgery due to aortic aneurysms 2. Must be 18 years or older Exclusion Criteria: For all patients: * Contra-indication for MRI * Heart pacemaker/defibrillator. * Electronic/implanted stimulators or devices, including deep brain stimulator, vagus nerve stimulator, bladder stimulator, spine stimulator, neurostimulators; implanted electrodes or wires. * Cochlear implant or other ear implants. * Implanted drug pumps (insulin, narcotic/pain medications, drugs to treat spasticity). * Programmable shunt. * Aneurysm clips and coils. * Stents (not located in heart). * Filters (for example, blood clot filters). * Metal fragment in your body or eye (eg, BBs, bullets, shrapnel, metal pieces or shavings). * Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD * Presence of A-V fistula or intracardiac shunts * Moderate or severe dysfunction in multiple valves * Patients with significant claustrophobia * Patients unable to pedal a supine bicycle * Those who require supplemental oxygen Specific Exclusion Criteria: 1. Healthy controls for baseline comparison 1. Excluded if using cardioprotective medication 2. Have a bicuspid aortic valve diagnosed using MRI 2. Pre-operative aneurysm patients: imaged pre-operatively and at 12 months a. Patients with traumatic aortic rupture
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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