Could an 'Exercise-in-a-Pill' replace workouts for heart failure?
NCT ID NCT05696652
First seen Feb 16, 2026 · Last updated Jun 19, 2026 · Updated 15 times
Summary
This study from Stanford University is looking at what happens inside the body when people with heart failure exercise. Researchers will measure thousands of proteins in the blood before and after a single workout, and again after a 12-week cardiac rehab program. By comparing these protein changes between those who exercise and those who wait, they hope to find molecules that could one day be turned into medicines that mimic exercise's benefits.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Stanford Health Care
RECRUITINGStanford, California, 94305, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
exercise (acute treadmill session and 12-week cardiac rehabilitation)
What this could lead to
If successful, this could identify key proteins that change with exercise, pointing toward new drug targets that mimic exercise benefits for heart failure patients.
What could go wrong
This is an early exploratory study with only 90 participants. It measures protein changes, not clinical outcomes, so it may not lead to any new treatments.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.