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Exercise hormone irisin may shield elderly brains from Post-Surgery confusion

NCT ID NCT07424170

Knowledge-focused Sponsor: Peking University People's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 11, 2026 · Updated 2 times

Summary

This observational study looks at how a protein called irisin, released during exercise, might protect the brain and lower the risk of postoperative delirium in older adults. Researchers will enroll 140 people aged 65 and older who are having non-cardiac surgery under spinal anesthesia. They will measure irisin levels in spinal fluid and track delirium for five days after surgery to see if daily activity and irisin are linked to better brain outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients scheduled for elective surgery at Peking University People's Hospital.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥ 65 years; * Classified as ASA physical status I to III; * Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia; * Expected surgical duration of at least 2 hours; * Voluntarily provide written informed consent and agree to participate in this study. Exclusion Criteria: * Significant change in exercise status within the past 7 days due to injury or other reasons; * Contraindications to neuraxial anesthesia; * Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score \< 23; * Preoperative diagnosis of delirium; * History of traumatic brain injury or neurosurgery; * Long-term opioid use or history of alcohol abuse; * Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration); * Change in anesthesia method.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post operative delirium

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Peking University People's Hospital

    RECRUITING

    Beijing, Beijing Municipality, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.