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Can a simple insulin tweak prevent Exercise-Induced low blood sugar?

NCT ID NCT07550608

Knowledge-focused Sponsor: Naama Constantini Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether cutting basal insulin by half before exercise helps keep blood sugar stable in people with type 1 diabetes. Eighteen active adults using insulin pumps completed two treadmill sessions—one with the insulin reduction and one without. Researchers measured blood sugar every 10 minutes to compare how men and women respond, aiming to reduce the risk of hypoglycemia during exercise.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
50% pre-exercise basal insulin rate reduction
What this could lead to
If successful, this could lead to better exercise guidelines for people with type 1 diabetes, helping them avoid dangerously low blood sugar during physical activity.
What could go wrong
This is a small, completed study with only 18 participants, so results may not apply to everyone. The intervention is specific to insulin pump users and may not work for others.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

18 people

The number who actually took part.

Started

Oct 2023

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 45 years. * Diagnosis of Type 1 Diabetes (T1D) for at least 18 months. * Current use of an insulin pump (Continuous Subcutaneous Insulin Infusion - CSII) for diabetes management. * Regular physical activity level, defined as at least 150 minutes of aerobic exercise per week across three or more sessions for at least 4 weeks prior to the study. * Ability to perform 60 minutes of continuous treadmill running. * Aerobic fitness level (VO2peak) of ≥ 30 mL·kg-¹·min-¹ for females or ≥ 32 mL·kg-¹·min-¹ for males. Exclusion Criteria: * Most recent HbA1c \> 9.9% (85 mmol/mol). * C-peptide levels ≥ 0.7 nmol/L. * Presence of significant diabetes complications (e.g., proliferative retinopathy, nephropathy, or symptomatic neuropathy). * Use of concomitant medications affecting glucose metabolism other than insulin (e.g., steroids, SGLT2 inhibitors, GLP-1 receptor agonists, or non-selective beta-blockers). * History of hypoglycemia unawareness. * Occurrence of severe hypoglycemia resulting in seizure, coma, or hospitalization within the 6 months prior to recruitment. * Adherence to a low-carbohydrate or ketogenic diet (\<30 g of carbohydrates per day). * Current engagement in shift work. * For female participants: presence of primary or secondary amenorrhea (cessation of menstruation for \>12 months). * Uncontrolled hypertension (Systolic BP \> 200 mmHg or Diastolic BP \> 110 mmHg). * Known cardiovascular disease or significant cardiovascular risk factors (e.g., ischemic heart disease).

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Conditions

The condition(s) this trial relates to.

Motor Activity type 1 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 1 diabetes

Contacts and locations

Locations

  • Sylvan Adams Sport Institute, Tel Aviv University

    Tel Aviv, Israel

More trials for these conditions

Other studies related to the condition(s) this trial covers.