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Exercise as medicine: can a 12-week program reverse muscle loss in breast cancer survivors?

NCT ID NCT07732101

Symptom relief Sponsor: Capital Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a 12-week structured exercise program, called "Exercise for Muscle Health," can improve muscle mass, strength, and physical function in breast cancer survivors who have sarcopenia—a condition of muscle loss and weakness. About 104 women who have finished primary breast cancer treatment and meet sarcopenia criteria will be randomly assigned to either the exercise program plus health education or routine care with general activity advice. The study measures changes in muscle mass, grip strength, physical performance, and quality of life over several months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a 12-week structured exercise program called "Exercise for Muscle Health" combined with health education
What this could lead to
If it works, this could provide an evidence-based exercise program to help breast cancer survivors regain muscle and improve quality of life.
What could go wrong
This is a relatively small trial (104 participants) testing a new program, so results may not apply to all survivors. Exercise programs require adherence, and benefits may vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 104 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Female, aged ≥18 years; Pathologically confirmed diagnosis of breast cancer, having completed primary treatment (surgery, chemotherapy, radiotherapy, etc.) and currently in the rehabilitation phase (≥3 months after treatment completion); Meet sarcopenia diagnostic criteria assessed by trained researchers: for women aged ≥65 years, ASMI \< 0.57 and handgrip strength \< 18 kg; for women aged \<64 years, ASMI \< 0.63 and handgrip strength \< 20 kg; Provide informed consent and voluntarily participate in the study; Have basic communication and comprehension abilities. Exclusion Criteria: History of psychiatric disorders or consciousness impairment; Presence of exercise contraindications including severe cardiac, hepatic, or renal insufficiency, bone metastases, or uncontrolled hypertension; Major surgery or severe trauma within the past 3 months; Involuntary weight loss \>5% within the past 3 months, or presence of active progressive tumor burden (e.g., imaging evidence of significant metastasis or receiving palliative chemotherapy), suggesting tumor-driven cachexia; Currently participating in other exercise intervention studies or having completed other exercise programs within the past 6 months; Refusal of randomization.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Breast cancer Sarcopenia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Fifth Medical Center of Chinese PLA General Hospital (South Campus)

    Beijing, Beijing Municipality, 100054, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.