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Can exercise rebuild knee cartilage? new study investigates

NCT ID NCT06532851

Symptom relief Sponsor: Jordan University of Science and Technology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether progressive resistance exercises or aerobic exercises better improve knee cartilage and physical function in people aged 35-55 with degenerative meniscus tears. 45 participants will be split into three groups: resistance training, aerobic training, or standard care. The goal is to find which exercise approach works best and to prepare for a larger future study.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2023

Expected to finish

Mar 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

35 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Are between 35 and 55 years of age. 2. Have a symptomatic degenerative medial meniscus tear as evidenced by: * Presence of medial knee pain. * Medial joint line tenderness. * Pain and limited motion when attempting to perform a full squat and * Increased intra-meniscal signal on at least 2 consecutive MRI slices and 3. Have clearance from their personal physician to participate in an exercise program. Exclusion Criteria: 1. Radiographic evidence of OA (K-L grade 2 or above). 2. A repairable meniscus injury (longitudinal tear in the outer 1/3 of the meniscus). 3. A meniscus injury that requires meniscectomy (locked knee). 4. Prior or current ligament injury or surgery of the involved knee. 5. Prior or current injury or surgery to contra-lateral knee. 6. Pathological ligamentous laxity upon examination of the knee 7. An inflammatory arthritic condition or 8. Any injury or condition involving the lower extremities that affects their ability to walk. Because participation in this study requires undergoing MRI, subjects will be excluded if they: 1. If female, pregnant at the time of enrollment. 2. Had prior surgery for an aneurysm; any medical illness that may interfere with the patient's general fitness or exercise capability. 3. Had any contraindication with MRI. 4. Had surgery within the past two months. 5. Have a cardiac pacemaker.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Meniscus tear

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Jordan University of Science and Technology

    RECRUITING

    Irbid, Jordan

  • King Abdullah University Hospital

    RECRUITING

    Ar Ramtha, Jordan

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