Which exercise eases knee pain best? new trial tests two approaches
NCT ID NCT07298798
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to one of two groups and will exercise for 4 weeks. Researchers will measure pain levels and daily function using standard scales.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- exercise (closed kinetic chain and isometric exercises)
- What this could lead to
- If successful, this could show that specific exercises are more effective for reducing knee pain and improving daily function in women with osteoarthritis.
- What could go wrong
- This is a small, early-stage trial with only 70 participants, so results may not apply to everyone. The exercises may not provide lasting relief beyond the 4-week study period.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
70 people
The number who actually took part.
- Started
-
Nov 2023
- Expected to finish
-
Nov 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
35 to 60 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * Age between (35 to 60) years. * Gender: female. * The numerical pain rating scale (NPRS) is greater than three out often i.e. 3/10 score. * Patient experiences anterior knee pain due to such activities like squatting, prolonged sitting, running and stair climbing. * Patient with unilateral or bilateral knee pain with positive radiographic imaging. * Patients have grade 1 and 2 knee osteoarthritis (K\&L classification). Exclusion Criteria * Any past record of knee surgery. * Any past record of knee fracture. * Patients with any neurological disorder. * Cancer, malignancy or any bone tumor. * Comorbid like diabetes mellitus. * Any systemic inflammatory arthritis.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Knee osteoarthritis are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Saddar
Karachi, Pakistan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Taping techniques face off in knee pain trial
- Can robotic surgery personalize knee replacement?
- Custom knee guides put to the test in obese patients
- Can a shot of your own blood ease arthritic knees?
- 5,000 knee arthritis patients tracked to crack the treatment code
- Can a hydrogel injection ease knee arthritis pain?