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Exercise boosts brain and body in frail seniors, study hopes

NCT ID NCT07513701

Symptom relief Sponsor: The Hong Kong Polytechnic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether 3 months of aerobic and resistance training can improve physical reserve—the body's ability to handle stress—in 224 frail older adults living in the community. Researchers want to see if this exercise program helps preserve both physical mobility and cognitive function, even in people with signs of brain aging. Participants will do supervised exercises like jogging on the spot, agility drills, and weight training, and be compared to those receiving usual care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Aerobic and resistance training
What this could lead to
If successful, this exercise program could help frail older adults maintain their physical and mental abilities longer, even with underlying brain changes.
What could go wrong
This is a small, early-stage trial (224 participants) testing a behavioral intervention, not a drug. Results may not apply to all older adults, and benefits may be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 224 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. are community-dwelling (i.e., not residing in a nursing home or extended care unit) ; 2. scored \< 9/12 on the SPPB; 3. scored \>18/30 on the MoCA; 4. are able to walk independently; use of walking aid is acceptable; 5. are able to safely engage in exercise as indicated by the Physical Activity Readiness Questionnaire Plus33 and confirmed by their physician; 6. have internet at home; and 7. are able to provide written informed consent. Exclusion Criteria: 1. diagnosed with dementia or stroke; 2. self-report engaging in strength and balance training exercises \> two-times-per-week in the 3 months prior to screening; 3. unable to understand, speak, and read Cantonese/Chinese/English proficiently; and 4. contraindications for MRI such as MRI-incompatible implants.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Frailty at older adults

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Hong Kong Polytechnic University, Department of Rehabilitation Sciences

    RECRUITING

    Hong Kong, Hong Kong, 0000000, Hong Kong

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