Pump iron, boost brain? creatine and training tested for menopause
NCT ID NCT07027800
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether high-intensity resistance training plus creatine supplements can improve muscle quality and thinking skills in perimenopausal women. Fifty-five healthy women aged 38-60 took part, with some getting creatine, some a placebo, and some no supplement. The goal is to find simple ways to ease common menopause-related changes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Creatine monohydrate (dietary supplement)
- What this could lead to
- If it works, this could point toward a simple way to improve muscle strength and thinking skills during perimenopause.
- What could go wrong
- This is a small pilot study with only 55 women, so results may not apply to everyone. The supplement may cause digestive upset or not show clear benefits.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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55 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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38 to 60 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women transitioning through perimenopause (defined by the North American Menopause Society Menopause Health Questionnaire), with or without hormone therapy or experiencing two or more perimenopause-related symptoms, as determined from the validated North American Menopause Society * Women ≥38-60 yrs. * Recreationally active \[(≥30 minutes of moderate-intensity physical activity per week and \<3 times per week of progressive resistance training, as defined by the International Physical Activity Questionnaire (IPAQ)\] * Body mass index of 18.5-34.9 kg/m\^2 * Is at risk or has a current chronic disease that is not contraindicated by exercise, and could be improved by resistance exercise (i.e. type 2 diabetes, heart disease, hypertension, hypercholesterolemia, hyperthyroidism, depression, osteoporosis, etc.) Exclusion Criteria: * Experienced a musculoskeletal injury within the past three months that inhibits participation in the study. * Has chronic kidney disease, liver disease, chronic obstructive pulmonary disease, or cancer * Currently using medications that may directly impact the primary outcomes including: diuretics and corticosteroids). * Currently using creatine monohydrate or other performance-enhancing supplements * Has a self-identified or clinically diagnosed eating disorder * Currently pregnant or planning to become pregnant (determined from urine pregnancy test) * Currently nursing or have had a child within the previous 6 months * Has participated in another clinical trial within four weeks prior to enrollment that in the opinion of the PI would influence the results. * Has severely impaired hearing or speech or inability to speak English. * Unwilling or unable to comply with the study protocol, including abstaining from caffeine, tobacco, alcohol, and physical activity before testing days.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Applied Physiology Laboratory
Chapel Hill, North Carolina, 27713, United States
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