Exercise may slow brain decline in aging and early Alzheimer's
NCT ID NCT02520232
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether regular exercise can help slow down memory and thinking problems in older adults with early Alzheimer's disease and in healthy older adults. Researchers tested a program combining aerobic and strength exercises against stretching and balance exercises. The goal was to see if exercise improves brain function and blood flow. The study included 139 people aged 60 to 80.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Combination of aerobic and strength exercises
- What this could lead to
- If it works, this could point toward a non-drug way to slow cognitive decline in early Alzheimer's and healthy aging.
- What could go wrong
- This is a small, completed observational study, not a treatment trial. Results may not apply to everyone, and exercise may not improve thinking for all participants.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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139 people
The number who actually took part.
- Started
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Jun 2015
- Finished
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May 2018
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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60 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged between 60 and 80 years * Retired * Complete autonomy on the following four instrumental activities of daily living scales (IADL) : ability to use telephone, mode of transportation, responsibility for own medications and ability to handle finances, level of physical activity practice ≤ 2 * 18.5 ≤ BMI \< 40 * MMSE ≥ 25 * For prodromal Alzheimer Disease patients : subjective memory complaints of the participant, objective evidence of impaired encoding in episodic memory (Grober-Buschke free recall score \< 17). Exclusion Criteria: * Presence of a counter-indication for Magnetic Resonance Imaging , presence of a counter-indication for Positron Emission TomographyScan with \[18F\]-Flutemetamol, presence of any health problem preventing travel to the imaging service of the University Hospital, being under the legal guardianship of another person or being unable to provide consent to participate
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University Hospital Bordeaux, France
Bordeaux, 33076, France
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University Hospital, Poitiers
Poitiers, 86021, France
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