Nerve pain device study abandoned after only 2 patients
NCT ID NCT04649554
First seen Jan 05, 2026 · Last updated Jun 21, 2026 · Updated 35 times
Summary
This study tested a device called Exablate, which uses focused sound waves to treat areas of the brain linked to pain. The goal was to see if it could reduce pain and improve quality of life in people with chronic nerve pain. Only 2 people enrolled before the study was stopped, so no meaningful results were obtained.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Fondazione IRCCS Neurologico Carlo Besta
Milan, 20133, Italy
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Exablate (MRgFUS) device
What this could lead to
If it had worked, this could point toward a non-invasive treatment for chronic nerve pain.
What could go wrong
The study was terminated early with only 2 participants, so no reliable conclusions can be drawn. The approach may not be effective or safe for broader use.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.