Could less radiation be better for some throat cancer patients?
NCT ID NCT03822897
First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 35 times
Summary
This study is testing whether giving less radiation to the lymph nodes can reduce side effects for people with low-risk HPV-related throat cancer. The goal is to see if doctors can safely skip radiation to some lymph node areas without increasing the chance of the cancer coming back. About 100 patients are taking part, and they receive either radiation alone or radiation plus chemotherapy.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
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BCCA - Centre for the North
Prince George, British Columbia, V2M 7E9, Canada
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BCCA - Vancouver Cancer Centre
Vancouver, British Columbia, V5Z 4E6, Canada
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CIUSSS de l'Estrie - Centre hospitalier
Sherbrooke, Quebec, J1H 5N4, Canada
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CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
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Dr. H. Bliss Murphy Cancer Centre
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
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Hotel-Dieu de Quebec
Québec, Quebec, G1R 2J6, Canada
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Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, Ontario, L8V 5C2, Canada
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Kingston Health Sciences Centre
Kingston, Ontario, K7L 2V7, Canada
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Odette Cancer Centre
Toronto, Ontario, M4N 3M5, Canada
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Ottawa Hospital Research Institute
Ottawa, Ontario, K1H 8L6, Canada
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The Jewish General Hospital
Montreal, Quebec, H3T 1E2, Canada
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The Research Institute of the McGill University
Montreal, Quebec, H4A 3J1, Canada
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University Health Network
Toronto, Ontario, M5G 2M9, Canada
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy (with or without cisplatin chemotherapy)
What this could lead to
If successful, this could lead to a standard treatment that reduces side effects for patients with low-risk HPV-related throat cancer, improving quality of life without compromising cancer control.
What could go wrong
This is a phase 2 trial with only 103 participants, so results may not apply to all patients. Reducing radiation might increase the risk of cancer returning in the lymph nodes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.