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Can estrogen keep blood vessels young? new study investigates

NCT ID NCT04255160

Knowledge-focused Sponsor: University of Delaware Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the hormone estradiol affects blood vessel function in women going through perimenopause (the transition to menopause). Researchers will measure how well blood vessels widen and examine cells from veins. The goal is to understand why blood vessel health declines with age and how estradiol might help. The study involves 80 perimenopausal women aged 40-58.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2020

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 58 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Peri-menopausal women between 40-58 years of age with variable cycles as defined by increase in cycle length of greater than 7 days within ten consecutive cycles, or amenorrhea for more than 2 months, but less than 12 months. Exclusion Criteria: * Women who are pregnant, planning on becoming pregnant, or are breast feeding; * Women who have a history of cardiovascular disease, blood clots (e.g, pulmonary embolism or deep vein thrombosis), stroke, cancer, or liver disease; * Women who have a body mass index less than 18 or greater than 35kg/m2; * Women who use tobacco products; * Women who's blood pressure is greater than 140/90 mmHg, have been diagnosed by a physician with hypertension or are taking medication for high blood pressure; * Women who have a neurological disease, or diabetes; * Women who have had a hysterectomy or have used hormones (birth control or hormone replacement) within the past 3 months; * Women who have a latex allergy.

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Conditions

The condition(s) this trial relates to.

Aneurysm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Estrogen Perimenopause Vasodilation

Contacts and locations

Locations

  • University of Delaware

    Newark, Delaware, 19716, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.