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Could a hormone pill reignite desire? new trial tests estetrol for postmenopausal sexual arousal

NCT ID NCT06308614

Symptom relief Sponsor: Estetra Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This phase 2 trial tested whether estetrol (E4), a hormone pill, can help postmenopausal women with female sexual arousal disorder. 82 women took either estetrol or a placebo for 12 weeks. Researchers measured changes in sexual arousal and distress to see if the drug works better than a dummy pill.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
estetrol (E4)
What this could lead to
If it works, this could point toward a hormone-based treatment for sexual arousal difficulties in postmenopausal women.
What could go wrong
This is a small, early-phase proof-of-concept study with only 82 participants. The results may not show a clear benefit over placebo, and more research would be needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

82 people

The number who actually took part.

Started

Jan 2024

Finished

Apr 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Main Inclusion Criteria: • Hysterectomized postmenopausal women, ≥40 up to ≤65 years, diagnosed with Female Sexual Arousal Disorder Main Exclusion Criteria: * Not willing to stop any hormonal products during their participation in the study * History of unresolved sexual trauma or abuse that is contributing to any sexual dysfunction problem * Have experienced a recent major life stress or relationship discord that could interfere with sexual activity * Clinically significant abnormal gynecological findings * History of malignancy, with the exception of basal cell or squamous cell carcinoma of the skin * Systolic BP higher than 140 mmHg, diastolic BP higher than 90 mmHg * Is judged by the investigator to be unsuitable for any reason

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Conditions

The condition(s) this trial relates to.

physiological sexual disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sexual dysfunction, physiological

Contacts and locations

Locations

  • Estetra Study Site

    Mesa, Arizona, 85209, United States

  • Estetra Study Site

    Phoenix, Arizona, 85032, United States

  • Estetra Study Site

    Tucson, Arizona, 85715, United States

  • Estetra Study Site

    Pomona, California, 91767, United States

  • Estetra Study Site

    San Diego, California, 92111, United States

  • Estetra Study Site

    Jacksonville, Florida, 32256, United States

  • Estetra Study Site

    Miami, Florida, 33173, United States

  • Estetra Study Site

    New Port Richey, Florida, 34562, United States

  • Estetra Study Site

    Ocoee, Florida, 34761, United States

  • Estetra Study Site

    Orlando, Florida, 32801, United States

  • Estetra Study Site

    West Palm Beach, Florida, 33409, United States

  • Estetra Study Site

    Atlanta, Georgia, 30328, United States

  • Estetra Study Site

    Chicago, Illinois, 60643, United States

  • Estetra Study Site

    Omaha, Nebraska, 68114, United States

  • Estetra Study Site

    Las Vegas, Nevada, 89109, United States

  • Estetra Study Site

    Albuquerque, New Mexico, 87102, United States

  • Estetra Study Site

    Cleveland, Ohio, 44106, United States

  • Estetra Study Site

    Englewood, Ohio, 45322, United States

  • Estetra Study Site

    Memphis, Tennessee, 38119, United States

  • Estetra Study Site

    Houston, Texas, 77061, United States

  • Estetra Study Site

    Houston, Texas, 77074, United States

  • Estetra Study Site

    Salt Lake City, Utah, 84107, United States

  • Estetra Study Site

    Virginia Beach, Virginia, 23456, United States

  • Estetra Study Site

    Seattle, Washington, 98104, United States

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