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New combo aims to fight tough bladder cancer

NCT ID NCT03237780

First seen Jan 04, 2026 · Last updated Jun 18, 2026 · Updated 36 times

Summary

This study tests whether adding the chemotherapy drug eribulin to the immunotherapy atezolizumab works better than atezolizumab alone for people with advanced or spreading bladder cancer who cannot take standard cisplatin chemo. About 72 adults with recurrent or metastatic urothelial cancer will take part. The goal is to see if the combination shrinks tumors more effectively and to check for side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

  • City of Hope Upland

    Upland, California, 91786, United States

  • City of Hope at Irvine Lennar

    Irvine, California, 92618, United States

  • Keck Medical Center of USC Pasadena

    Pasadena, California, 91105, United States

  • Keck Medicine of USC Buena Park

    Buena Park, California, 90621, United States

  • Keck Medicine of USC Koreatown

    Los Angeles, California, 90020, United States

  • Los Angeles General Medical Center

    Los Angeles, California, 90033, United States

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California, 92868, United States

  • USC / Norris Comprehensive Cancer Center

    Los Angeles, California, 90033, United States

  • USC Norris Oncology/Hematology-Newport Beach

    Newport Beach, California, 92663, United States

  • University of Alabama at Birmingham Cancer Center

    Birmingham, Alabama, 35233, United States

  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, 95817, United States

  • University of Kansas Cancer Center

    Kansas City, Kansas, 66160, United States

  • University of Kansas Cancer Center - Lee's Summit

    Lee's Summit, Missouri, 64064, United States

  • University of Kansas Cancer Center - North

    Kansas City, Missouri, 64154, United States

  • University of Kansas Cancer Center at North Kansas City Hospital

    North Kansas City, Missouri, 64116, United States

  • University of Kansas Cancer Center-Overland Park

    Overland Park, Kansas, 66210, United States

  • University of Kansas Clinical Research Center

    Fairway, Kansas, 66205, United States

  • University of Kansas Hospital-Indian Creek Campus

    Overland Park, Kansas, 66211, United States

  • University of Kansas Hospital-Westwood Cancer Center

    Westwood, Kansas, 66205, United States

  • University of Pittsburgh Cancer Institute (UPCI)

    Pittsburgh, Pennsylvania, 15232, United States

Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma infiltrating bladder urothelial carcinoma malignant renal pelvis neoplasm renal pelvis carcinoma renal pelvis urothelial carcinoma stage IVb bladder cancer transitional cell carcinoma ureter cancer ureter transitional cell carcinoma urethra cancer urethra transitional cell carcinoma Urethral Neoplasms Urinary Bladder Neoplasms urothelial carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.