New injection could offer quick relief for acute back pain
NCT ID NCT07434024
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether an ultrasound-guided nerve block injection can quickly reduce pain and improve movement in people with sudden, non-specific low back pain. 300 adults with severe pain and trouble walking will receive either a local anesthetic or a saline placebo injection. The goal is to see if the block helps them get out of bed and move more easily before leaving the hospital.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- local anesthetic (or isotonic saline as placebo)
- What this could lead to
- If it works, this could offer a new, non-opioid option for quickly easing severe low back pain in the emergency room.
- What could go wrong
- This is an early-stage trial with no phase assigned, and the placebo group also receives an injection, so the true benefit of the anesthetic may be small. Results may not apply to all types of back pain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Jan 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult (≥ 18 years); * Non-specific low back pain (≤ 5 days); * Pain score (VAS) ≥ 5 (during mobilization); * Inability to walk easily (failure of the "Get Up and Go" test in less than 20 seconds). Exclusion Criteria: * Low back pain of known specific origin: spine surgery, spine trauma, discal hernia, facet joint, radicular (sciatica, cruralgia, meralgia paresthetica), muscle pain, cancer-related or rheumatological disease; * Referred or chronic pain; * Patients with opioids (acute or chronic pain and/or misuse); * Contraindication to regional anaesthesia; * Contraindication to ropivacaine, dexamethasone, sodium chloride, NSAID, paracetamol, tramadol; * Known hypersensitivity to ropivacaine, dexamethasone, other amide-type local anesthetics, or any of the excipients; * Addiction to drugs, alcohol or medication; * Patients with anticoagulants for a curative use (not preventive); * Patients with cancer or risk of bone metastasis or; severe osteoporosis; * Acute inflammatory diseases (e.g., rheumatoid arthritis, ankylosing spondylitis…); * Patient with severe hypotension or uncontrolled hypertension or; Heart Block (uncorrected second- or third-degree heart block without a pacemaker) or; severe bradycardia; * Patients with severe liver or renal disease or peptic ulcer disease; * Presence of infection or sepsis at the injection site; * Patients with uncontrolled bacterial, viral, or protozoan infections or; systemic fungal infections or; active untreated tuberculosis or; active ocular herpes simplex infections; * Patients with uncontrolled diabetes mellitus; * Patients with glaucoma or history of severe glaucoma; * Patients with severe psychiatric conditions; * Subject unable to read or/and write (inability to complete a self-administered questionnaire); * Unavailability for follow up during 6 months; * Participation in another clinical trial involving an investigational medicinal product or medical device within 4 weeks preceding the screening date; * Pregnancy in progress or planned during the study period or breastfeeding women (Art. L1121-5 of the French Public Health Code); * Women of childbearing potential (WOCBP) without a negative of highly sensitive pregnancy test before inclusion or not using a highly effective method of contraception; * Patients protected by law (Art. L1121-6 and L1121-8 of the French Public Health Code): Individuals deprived of their liberty by judicial or administrative decision, minors, adults under law protection or unable to express their consent or patient under guardianship or curatorship; * Patients not covered by a French social security scheme or not benefiting from such a scheme; * Absence of signed informed consent form before inclusion from the patient; * Patient already included in the study.
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As listed by the trial registrant
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How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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