Could a tiny epinephrine shot prevent dangerous drops in blood pressure during C-Sections?
NCT ID NCT07480889
First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 1 time
Summary
This study tests whether giving a small dose of epinephrine (adrenaline) right after spinal anesthesia, followed by a steady infusion, can prevent blood pressure drops during cesarean sections. Researchers will compare this approach to epinephrine infusion alone in 100 women aged 18-35. The goal is to see if the bolus provides better stability without increasing risks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Epinephrine (adrenaline)
- What this could lead to
- If successful, this could offer a simple way to prevent dangerous blood pressure drops during C-sections, improving safety for mothers.
- What could go wrong
- This is a small, early-phase trial with only 100 participants, so results may not apply to all patients. Epinephrine can cause side effects like rapid heart rate or high blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
80 people
The number who actually took part.
- Started
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Mar 2026
- Finished
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Aug 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 35 years
- Sex
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Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age: 18 to 35 years. 2. American Society of Anesthesiologists (ASA) physical status II. 3. Undergoing Elective Lower Segment Cesarean Section under Spinal Anesthesia. Exclusion Criteria: 1. Uncontrolled cardiac morbidities as reduction of ejection fraction\< 60%, History (within 3months) of myocardial infarction, cerebrovascular accident, transient ischemic attacks or coronary artery disease/stents 2. Poorly controlled Hypertensive disorders of pregnancy 3. Peripartum bleeding 4. Multiple pregnancies (e.g., twin gestations) 5. Coagulation disorders defined as platelet count \<100,000/μL, INR \>1.4, or known inherited clotting factor deficiency. 6. Baseline systolic blood pressure (SBP) \< 100 mmHg or \>130 mmHg 7. Refusal of patients.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kasr Alaini hospital
Cairo, Egypt
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