New hope for tough leukemia: drug combo shows promise in kids

NCT ID NCT03263936

Completed Disease control Sponsor: Therapeutic Advances in Childhood Leukemia Consortium Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated May 25, 2026 · Updated 27 times

Summary

This study tested a new way to treat children and young adults (ages 1 to 25) with acute myeloid leukemia (AML) that has come back or is hard to treat. The approach uses two drugs (decitabine and vorinostat) to 'reprogram' leukemia cells before giving standard chemotherapy (FLAG). The main goal was to find a safe dose of decitabine when used in this combination. 37 participants were enrolled, and the study focused on measuring side effects to determine the highest safe dose.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Contacts and locations

Show contact details

Locations

All Children's Hospital

St. Petersburg, Florida, 33701, United States
British Columbia Children's Hospital

Vancouver, British Columbia, V6H 3V4, Canada
C.S. Mott Children's Hospital

Ann Arbor, Michigan, 48109-0914, United States
CS Mott Children's Hospital, Ann Arbor

Ann Arbor, Michigan, 48109, United States
Children's Healthcare of Atlanta, Emory University

Atlanta, Georgia, 30322, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital New York-Presbyterian

New York, New York, 10032, United States
Children's Hospital Orange County

Orange, California, 92868, United States
Children's Hospital at Westmead

Westmead, Australia
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
Johns Hopkins University

Baltimore, Maryland, 21231, United States
Levine Children's Hospital

Charlotte, North Carolina, 28203, United States
Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
National Cancer Institute, Pediatric Oncology Branch

Bethesda, Maryland, 20892, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
New York University Medical Center

New York, New York, 10016, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Primary Children's Hospital

Salt Lake City, Utah, 84113, United States
Sainte Justine University Hospital

Montreal, Quebec, Canada
Seattle Children's Hospital

Seattle, Washington, 98105, United States
Sidney Kimmel Cancer Center at Johns Hopkins

Baltimore, Maryland, 21231, United States
Sydney Children's Hospital

Randwick, New South Wales, 2031, Australia
Texas Children's Cancer Center, Baylor

Houston, Texas, 77030, United States
The Children's Hospital, University of Colorado

Aurora, Colorado, 80045, United States
UCSF School of Medicine

San Francisco, California, 94158, United States
University of Miami

Miami, Florida, 33136, United States

Conditions

Explore the condition pages connected to this study.

ACUTE MYELOGENOUS LEUKEMIA