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Could a simple additive to epidurals prevent chronic pain after surgery?

NCT ID NCT07292324

Symptom relief Sponsor: Udayana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding dexmedetomidine to a standard epidural painkiller (bupivacaine) improves pain control for women undergoing gynecologic laparotomy. 62 women received either the standard epidural or one with dexmedetomidine added. Researchers measured pain levels, painkiller use, and inflammation markers for 24 hours after surgery, and checked for chronic pain 3 months later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine (added to bupivacaine epidural)
What this could lead to
If it works, this could offer better short-term pain relief and lower the chance of long-term pain after gynecologic surgery.
What could go wrong
This is a small, completed Phase 4 trial with 62 participants, so results may not apply to everyone. Adding dexmedetomidine may cause side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

62 people

The number who actually took part.

Started

Aug 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 55 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 30-55 years * ASA physical status I-III * Body Mass Index (BMI) 18 - 29.9 kg/m2 * Patients undergoing gynecologic laparotomy Exclusion Criteria: * Contraindications for regional anesthesia * Allergy or contraindication to dexmedetomidine * Routine use of antidepressants or anticonvulsants * Chronic opioid consumption (equivalent to \>30 mg oral morphine per day for \>1 month) * History of Chemotherapy-Induced Peripheral Neuropathy (CIPN) * Active systemic autoimmune disease or receiving immunosuppressant therapy (e.g., Systemic Lupus Erythematosus, Rheumatoid Arthritis, Multiple Sclerosis) * Inability to use the Visual Analogue Scale (VAS) or operate the Patient-Controlled Epidural Analgesia (PCEA) device * Coagulation disorders (prolonged hemostasis) * Refusal to participate

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Conditions

The condition(s) this trial relates to.

female reproductive system disorder Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic post-surgical pain Gynecologic disease Post operative pain, acute

Contacts and locations

Locations

  • Prof. Dr. I.G.N.G Ngoerah Central General Hospital

    Denpasar, Bali, 80114, Indonesia

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