Laser showdown: which device rejuvenates skin best?
NCT ID NCT03767972
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study aimed to compare several energy-based devices (like lasers and radiofrequency) for skin rejuvenation on the face, hands, and other areas. It enrolled 24 adults with signs of skin aging. The trial was terminated early, so the planned comparison of effectiveness and side effects was not completed.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Energy-based devices (lasers and radiofrequency devices such as Fraxel Restore, Helios III, PicoWay, Halo, ThermiVa, DiVa)
- What this could lead to
- If successful, this could show which energy-based device works best for skin rejuvenation with fewer side effects.
- What could go wrong
- The trial was terminated early, so we have limited data. It is a small, early study comparing many devices, making it hard to draw firm conclusions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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24 people
The number who actually took part.
- Started
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Feb 2018
- Finished
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Sep 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Exhibit skin aging and will benefit from skin rejuvenation treatment of the face, neck/décolletage, trunk, hands, upper and lower extremities and/or vagina as determined by the investigator/physician. 2. Subjects between the ages of 18-85 years old, at the time of consent. 3. Subjects may be male or female. 4. Subjects with Fitzpatrick Skin type I-III (Fraxel Restore, Helios III, Pico) or I-VI (Halo, ThermiVa, DiVa). 5. Subjects must be able and willing to give written informed consent and to comply with the requirements of this protocol. The consent form has been standardized in English. For those patients who do not read and understand English, a consent form will be standardized and provided in a language that they read and understand if possible. Exclusion Criteria: 1. Children and adolescents (less than 18 years old). 2. Subjects who are not willing or able to provide written consent. 3. Individuals with any significant medical history including skin disorders and eating disorders as determined by the investigator/physician. 4. Subjects on any substances affecting blood coagulation (including but not limited to aspirin and other non-steroid anti-inflammatory drugs, warfarin, vitamin E, fish oil, heparin, low-molecular weight heparin, novel anti-coagulants). 5. Subjects with known blood coagulopathies. 6. Subjects with a compromise of local blood supply (including but not limited to recent surgery, severe scarring, autoimmune diseases involving the face, neck/décolletage, trunk, hands or lower extremities such as lupus, morphea, sarcoid or mixed connective tissue disease) (dependent on their treatment group). 7. Subjects who have received energy-based rejuvenation treatment of the face, neck/décolletage, trunk, hands, upper and lower extremities, and/or vagina within the past 3 months (dependent on the area they are planning to treat). 8. Subjects who meet any of the contraindication criteria listed in the product information for the device the subject will be treated with. 9. Subjects who are self-reported to be currently pregnant or lactating at the time of treatment.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of California, Irvine, Dermatology Clinical Research Center
Irvine, California, 92697, United States
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