Tiny nerves may explain endometriosis pain – study hints at smarter surgery
NCT ID NCT06286371
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at tissue samples from 15 women with deep endometriosis who had laparoscopic surgery. Researchers measured nerve and blood vessel density in the peritoneum near endometriosis nodules and checked pain scores before and after surgery. The goal was to see if these changes relate to pain and help determine the best surgical margin for removal. No new treatment was tested; the study aims to improve future surgical planning.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help surgeons know how much tissue to remove during endometriosis surgery to reduce pain more effectively.
- What could go wrong
- This is a very small, completed observational study (15 people). It does not test a new treatment, so any surgical guidance is still theoretical.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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15 people
The number who actually took part.
- Started
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Dec 2023
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 45 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with suspicion of deep endometriosis (Physical Examination and MRI) * Patients with ineffective response to medical therapy * Patients who undergo laparoscopic conservative endometriosis surgery (douglasectomy) Exclusion Criteria: * Patients with malignity suspicion * Patients with extensive surgery (hysterectomy, ovariectomy) * Patients with previous endometriosis or another pelvic surgery * Patients with oocyte pick up procedure history * Patients with pelvic inflammatory disease history
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Uludag University Faculty Hospital
Bursa, Gorukle, 16285, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Appendix: the hidden driver of endometriosis pain?
- Allergy pill put to the test against endometriosis pain
- Can ultrasound and tissue clues reveal which endometriosis lesions carry cancer risk?
- Can AI personalize exercise to ease pelvic pain?
- Can AI learn to spot endometriosis and fibroids on ultrasound?