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Tooth-Enamel gel may boost dental implant healing

NCT ID NCT07727655

Disease control Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 27, 2026 · Last updated Sep 17, 2026 · Updated 3 times

Summary

This trial tests whether applying a gel made from tooth-enamel proteins (enamel matrix derivative) during immediate dental implant placement can improve healing and implant stability. Adults aged 18 to 45 who need a lower molar replaced will receive either the gel or standard implant placement. Researchers will measure implant stability and bone changes over six months to see if the gel helps the implant fuse with the jawbone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a gel made from tooth-enamel proteins (enamel matrix derivative, Emdogain)
What this could lead to
If it works, this could lead to a simple way to improve dental implant success and bone healing after tooth extraction.
What could go wrong
This is a small, early-stage trial with only 24 people, so results may not apply to everyone. The gel is generally safe but could cause local swelling or discomfort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with non-restorable mandibular molar requiring dental extraction. 2. Patient medically free from systemic diseases that absolutely contraindicate implant surgery. 3. Age range: from (18 to 45) years. 4. Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration (8-12mm). 5. Extraction sockets with intact bony walls and interradicular bone. 6. Jumping gap more than 2mm. 7. Patients with good oral hygiene. 8. Patients willing to participate in the study's follow-up intervals. Exclusion Criteria: 1. Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site impaired the immediate implant placement. 2. smoker patients. 3. Pregnant patients. 4. Patients with para-functional habits (bruxism and clenching)

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Conditions

The condition(s) this trial relates to.

Tooth Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tooth loss

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Mansoura University - Oral and Maxillofacial Surgery Department

    RECRUITING

    Al Mansurah, Dakahlia Governorate, Egypt

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