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Could a gentle zap to the scalp sharpen the Parkinson's brain?

NCT ID NCT05808504

Symptom relief Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study investigates whether a painless, low-intensity electrical current applied to the scalp can improve cognitive function — specifically the ability to stop an action when needed — in people with Parkinson's disease. The trial includes 50 Parkinson's patients and 40 healthy volunteers. Participants perform a computer task while brain activity is recorded, before and after real or sham stimulation, to see if the stimulation boosts inhibition and related brain networks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial alternating current electrical stimulation
What this could lead to
If it works, this could point toward a non-invasive, drug-free way to ease cognitive symptoms in Parkinson's disease.
What could go wrong
This is an early-stage study with a small number of participants. The stimulation may not improve cognition, and benefits might not last or apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 90 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: For all participants: * Affiliation to a social security scheme or beneficiary of such a scheme. * Age over 18 years old. * Age less than 75 years old * Correct or correctly corrected view (on simple declaration by the patient). * Subject having received information on the protocol and having provided informed and written consent to participate. Criteria exclusive to patients: \- Idiopathic Parkinson's disease according to United Kingdom Parkinson's criteria Brain Bank disease (Hughes et al., 1992). Exclusion Criteria: For all participants: * Major cognitive impairment (Moca \< 22) or severe neurocognitive disorder according to DSM-V (Diagnostic and statistical manual of mental disorders -V); * Motor difficulties preventing the achievement of the task. * Drug or alcohol addiction. * Adult subject to legal protection (safeguard of justice, curatorship, guardianship), persons deprived of liberty. * Present or past moderate to severe psychiatric pathology (obsessive compulsive, bipolar disorder, schizophrenia, etc.). * Potential for pregnancy or confirmed pregnancy. A pregnancy test will be performed on inclusion.for women of childbearing age. Criteria exclusive to patients: * Present or past neurological pathology other than Parkinson's disease (accident stroke, head trauma, etc.). * Deep brain stimulation treatment. Exclusive to healthy participants: \- Present or past neurological pathology.

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Conditions

The condition(s) this trial relates to.

Inhibition, Psychological Neurobehavioral Manifestations Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • CHU de Rennes

    Rennes, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.