Stockings or not? major trial tests if blood thinners alone prevent clots after joint replacement.

NCT ID NCT06563531

Knowledge-focused Sponsor: Clinique Pasteur Lanroze Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether patients recovering from hip or knee replacement can safely skip elastic compression stockings and rely only on blood-thinning drugs to prevent dangerous blood clots. Over 1,200 participants will be randomly assigned to receive either drugs plus stockings or drugs alone, and followed for 90 days. The goal is to see if the drug-only approach is just as effective at preventing clots and pulmonary embolism.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: pharmacological thromboprophylaxis (blood-thinning drugs)
What this could lead to: If successful, this could simplify recovery after hip or knee replacement by removing the need for uncomfortable compression stockings.
What could go wrong: This is an early-stage study comparing two prevention methods; it may find that skipping stockings increases clot risk, so results are not yet practice-changing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 1,274 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * first line and non-traumatic total hip or knee arthroplasty * Patient included in an Enhanced Rehabilitation after Surgery (ERS) or "fast-track" protocol, or scheduled as an outpatient. Exclusion Criteria: * Patient requiring long-term anticoagulation for pre-existing co-morbidity * Patients with coagulation disorders (hypercoagulability) * Patient undergoing thrombogenic pharmacological treatment * History of obliterative arteriopathy of the lower limbs * Arterial disease * Obesity * Heart failure * Chronic bronchopneumopathy * Lymphedema * Chronic inflammatory disease * Permanent wearing of elastic restraints * Proximal or distal arterial bypass surgery * Creatinine clearance \< 15 ml/min * Inability to give consent * Revision surgery for hip or knee prosthesis * Metastatic cancer * Life expectancy less than 3 months * Allergy to socks or compression stockings * Patients presenting one or more exclusion criteria for the fast-track protocol (severe or poorly-balanced associated conditions such as diabetes or immunodepression, inability to contact the doctor or hospital department if necessary, pre-operative ASA score greater than or equal to 4). * Adults under guardianship or curatorship * Vulnerable persons in accordance with article L1121-6 of the CSP (French Public Health Code)

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Conditions

The condition(s) this trial relates to.

pulmonary embolism prevention target thrombophilia due to thrombin defect prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthroplasty complications

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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Stockings or not? major trial tests if blood thinners alone prevent clots after joint replacement.

What the study statuses mean