Army study: fiber fuel may improve 5K run times
NCT ID NCT06054607
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether short-chain fatty acids (SCFAs), which are produced when gut bacteria break down certain fibers, can improve aerobic endurance. 21 healthy, active adults ate a low-fiber diet with either a SCFA-boosting starch or a regular starch for one week, then did a 5km treadmill run. Researchers measured run time, muscle fuel, and metabolism to understand how SCFAs affect performance.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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21 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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May 2025
- Lead sponsor
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A government agency
The lead sponsor is a US federal agency other than the NIH.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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17 to 39 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men and women aged 18 - 39 years (active-duty personnel who are 17 yr of age will also be allowed to participate). * In good health. * Routinely participate in moderate or higher intensity aerobic and/or resistance exercise at least 4 days per week for ≥20 min/d. * Meet Army weight for height and body composition standards as defined in Army Regulation 600-9. * Self-reports a usual bowel movement frequency of every other day or more often. * Willing to refrain from the use of caffeine, alcohol, and nicotine while consuming study diets. * Willing to refrain from all dietary supplements beginning 2 weeks prior to study start and throughout study participation. * Willing to refrain from consumption of any foods containing live microorganisms (e.g., yogurt, kefir, kombucha) or added prebiotics (e.g. Fiber One products) beginning 2 weeks prior to study start and throughout study participation. * Willing to participate in all study procedures. * Females must have normal menstrual cycles between 26-32 days in duration; 5 menstrual cycles within the past 6 months; or be using an oral/hormonal contraceptive which contains low-dose estrogen/progesterone to maintain continuous levels throughout the 28-day cycle (i.e., no placebos). Exclusion Criteria: * Females who are pregnant, expecting to become pregnant during the study, or breastfeeding. * Any of the following medical conditions: Cardiac disease (including arrhythmia or fast or skipped heart beats) Hypertension Musculoskeletal injuries that compromise exercise capability Metabolic or cardiovascular abnormalities (e.g., kidney disease, diabetes, etc.) Disease of the GI tract including, but not limited to diverticulitis, inflammatory bowel disease, irritable bowel syndrome, peptic ulcer disease, Crohn's disease, and ulcerative colitis Allergy to skin adhesive or Lidocaine (or other local anesthetic being used in place of Lidocaine) Suspected or known strictures, fistulas, or physiological/mechanical GI obstruction History of gastric bezoar Swallowing disorders; severe dysphagia to food or pills Implanted or portable electro-mechanical medical devices (e.g., pacemaker) * Colonoscopy within 3 months of study participation. * Any use of antibiotics or antimycotics, except topical antibiotics/antimycotics, within 3 months of study participation. * Regular (i.e., weekly or more frequent) use of over-the-counter medications (including antacids, laxatives, stool softeners, and anti-diarrheals) unless approved by study PI. * Use of medication (i.e., diabetes medications, statins, corticosteroids, etc.) that affects macronutrient utilization and/or the ability to participate in strenuous exercise. * Anemia (HCT \<38 for men and \<34 for women) or Sickle Cell Anemia/Trait. * Not willing or able to follow all study procedures and diet/exercise restrictions. * Allergies, intolerances, unwillingness or inability to eat provided foods and beverages. * Following vegetarian/vegan diet or other highly restrictive diet (e.g., ketogenic diet, very high protein diet, Paleo diet, etc.). * Any previous blood donation within the previous 8 weeks that when combined with the volume of blood collected for the study within any 8-week period would exceed 550mL.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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United States Army Research Institute of Environmental Medicine
Natick, Massachusetts, 01760, United States
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