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Could a simple leg cuff cut stroke risk? new study tests EECP therapy

NCT ID NCT03921827

Disease control Sponsor: National University of Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether Enhanced External Counterpulsation (EECP) therapy, a non-invasive treatment using leg cuffs to boost blood flow, can improve brain circulation in people with severe narrowing of key brain arteries. The 130 participants had recently experienced a stroke or mini-stroke and had poor blood flow reserve. The goal was to see if EECP could increase blood flow reserve by at least 4% and reduce the risk of another stroke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Enhanced External Counterpulsation (EECP) therapy
What this could lead to
If it works, this could offer a non-invasive way to improve brain blood flow and lower the chance of another stroke in people with severe artery narrowing.
What could go wrong
This is a completed early-stage trial with 130 participants, so results may not apply to everyone. The therapy may not improve blood flow enough or reduce stroke risk as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

130 people

The number who actually took part.

Started

Jan 2019

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with recent stroke/TIA and severe stenosis of intracranial ICA or MCA and impaired CVR within previous three months but not before 3 weeks after acute stroke. This is to differentiate between patients with a long-standing fixed-stenosis from patients with partially recanalized intracranial artery (masquerading as severe stenosis). 2. Age \>21 years Exclusion Criteria: 1. Patients with atrial fibrillation/ arrhythmias. 2. Within 2 weeks of cardiac catheterization or arterial puncture at femoral puncture site. 3. Decompensated heart failure , usually class 3 or 4 4. LV EF \<30% 5. Moderate or severe AR 6. Persistent and uncontrolled hypertension (BP persistently \>160/100 mmHg) 7. Bleeding diathesis 8. Active thrombophlebitis/ venous disease of lower limbs 9. Severe lower extremity vaso-occlusive disease 10. Presence of a documented aortic aneurysm/ dissection requiring surgical repair 11. Pregnancy

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Conditions

The condition(s) this trial relates to.

cerebral artery stenosis ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic stroke

Contacts and locations

Locations

  • National University Hospital

    Singapore, 119228, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.