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Could this mRNA vaccine stop the virus behind mono and certain cancers?

NCT ID NCT05164094

Vaccine Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing an experimental mRNA vaccine called mRNA-1189 to see if it can safely prevent Epstein-Barr virus (EBV) infection in healthy people aged 10 to 30. EBV is a common virus that can cause mononucleosis and has been linked to some cancers. The vaccine is given as a shot, and researchers will monitor side effects and measure the body's immune response. About 867 participants will take part in this early-stage trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

867 people

The number who actually took part.

Started

Dec 2021

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

10 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * According to the assessment of the investigator, is in good general health and can comply with study procedures. Part A: Healthy adult from 18 to 30 years of age (inclusive) at the time of consent (Screening Visit, Day 0). Part B: Healthy baseline EBV-seronegative adolescents from 12 to \<18 years of age at the time of consent (Screening Visit, Day 0). Part C: Healthy adolescents and adults from 10 to 21 years of age (inclusive) at the time of consent (Screening Visit, Day 0). Exclusion Criteria: * Has had significant exposure to someone with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or COVID-19 in the past 14 days prior to the screening visit, if the participant has not been fully vaccinated against COVID-19 at least 14 days prior to the screening visit. * Has symptomatic acute or chronic illness requiring ongoing medical or surgical care, to include changes in medication in the past 2 months indicating that chronic illness/disease is not stable (at the discretion of the investigator). * Significant, progressive, unstable or uncontrolled clinical condition, including any condition that may affect participant safety, assessment of study endpoints, assessment of immune response, or adherence to study procedures per investigator judgement. * Has a history of myocarditis, and/or pericarditis. * Has received or plans to receive any licensed or authorized vaccine, to include COVID-19 vaccines, ≤28 days prior to the first injection (Day 1) or plans to receive a licensed vaccine within 28 days before or after any study vaccine injection, with the exception of licensed influenza vaccines, which may be received more than 14 days before or after any study vaccine injection. Note: Other inclusion and exclusion criteria may apply.

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Conditions

The condition(s) this trial relates to.

infectious mononucleosis Epstein-Barr virus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epstein-Barr virus infection

Contacts and locations

Locations

  • ACRC Trials

    Frisco, Texas, 75024, United States

  • ACRC Trials - Hunt - PPDS

    Carrollton, Texas, 75010, United States

  • ACRC Trials - Legacy Medical Village Headquarters

    Plano, Texas, 75024-4174, United States

  • Acclaim Clinical Research

    San Diego, California, 92120, United States

  • Alliance for Multispecialty Research LLC, East Wichita

    Wichita, Kansas, 67207, United States

  • Alliance for Multispecialty Research, LLC

    Las Vegas, Nevada, 89119, United States

  • Alliance for Multispecialty Research, LLC

    Norfolk, Virginia, 23502, United States

  • Alliance for Multispecialty Research, LLC - El Dorado - PPDS

    El Dorado, Kansas, 67042-2187, United States

  • Artemis Institute For Clinical Research LLC - Riverside - Headlands - PPDS

    Riverside, California, 92503, United States

  • Benchmark Research - Austin - PPDS

    Austin, Texas, 78705, United States

  • Benchmark Research - Colton - HyperCore - PPDS

    Colton, California, 92324, United States

  • Benchmark Research - Fort Worth - HyperCore - PPDS

    Fort Worth, Texas, 76135, United States

  • California Research Foundation - 4180 Ruffin Rd

    San Diego, California, 92123-1881, United States

  • Cedar Health Research - Fort Worth - PPDS

    Dallas, Texas, 75251, United States

  • CenExel iResearch, LLC

    Hollywood, Florida, 33024, United States

  • Center For Clinical Trials LLC -Paramount

    Paramount, California, 90723-5459, United States

  • Charlottesville Medical Research Center

    Charlottesville, Virginia, 22911, United States

  • Clinical Research Atlanta - Headlands - PPDS

    Stockbridge, Georgia, 30281-9054, United States

  • Clinical Research Institute, Inc.

    Minneapolis, Minnesota, 55402, United States

  • Clinical Research Partners LLC - Richmond - ERN - PPDS

    Richmond, Virginia, 23226-3787, United States

  • Coastal Carolina Research Center

    North Charleston, South Carolina, 29405, United States

  • Coastal Pediatric Associates

    Charleston, South Carolina, 29414-5834, United States

  • DM Clinical Research

    River Forest, Illinois, 60305, United States

  • DM Clinical Research

    Southfield, Michigan, 48076, United States

  • DM Clinical Research - Texas Center For Drug Development - ERN - PPDS

    Houston, Texas, 77065, United States

  • DM Clinical Research - Texas Center For Drug Development - ERN - PPDS

    Tomball, Texas, 77375, United States

  • Fomat Medical Research

    Oxnard, California, 93030, United States

  • Great Lakes Research Institute

    Southfield, Michigan, 48075, United States

  • Health Research of Hampton Roads Inc. - Newport News

    Newport News, Virginia, 23606-4537, United States

  • Helios Clinical Research

    Houston, Texas, 77008, United States

  • Jacksonville Center For Clinical Research - ERN - PPDS

    Jacksonville, Florida, 32216-4357, United States

  • Johnson County Clin-Trials

    Lenexa, Kansas, 66219, United States

  • Lucas Research

    Morehead City, North Carolina, 28557, United States

  • Lucas Research

    New Bern, North Carolina, 28562, United States

  • Lynn Health Science Institute

    Oklahoma City, Oklahoma, 73112, United States

  • Medical Affiliated Research Institute

    Huntsville, Alabama, 35801, United States

  • Michael W Simon MD, PSC

    Lexington, Kentucky, 40517-8379, United States

  • Olivo Medical and Wellness Center

    Chicago, Illinois, 60618-8101, United States

  • Orange County Research Center

    Tustin, California, 92780, United States

  • Peninsula Research Associates - Headlands Research - PPDS

    Rolling Hills, California, 90274, United States

  • Quality Clinical Research - ClinEdge - PPDS

    Omaha, Nebraska, 68112, United States

  • Senders Pediatrics

    South Euclid, Ohio, 44121, United States

  • Smart Cures Clinical Research

    Anaheim, California, 92806, United States

  • Sundance Clinical Research - ERN - PPDS

    St Louis, Missouri, 63141, United States

  • Tanner Clinic

    Layton, Utah, 84041, United States

  • Tekton Research - Texas - Platinum - PPDS

    Austin, Texas, 78745, United States

  • UMass Memorial Medical Center

    Worcester, Massachusetts, 01605, United States

  • Velocity Clinical Research

    Meridian, Idaho, 83642, United States

  • Velocity Clinical Research

    Valparaiso, Indiana, 46383, United States

  • Velocity Clinical Research

    East Syracuse, New York, 13057, United States

  • Velocity Clinical Research

    Anderson, South Carolina, 29621, United States

  • Velocity Clinical Research - Austin - PPDS

    Cedar Park, Texas, 78613-3936, United States

  • Velocity Clinical Research - Banning - PPDS

    San Bernardino, California, 92220-3082, United States

  • Velocity Clinical Research - Binghamton

    Binghamton, New York, 13901, United States

  • Velocity Clinical Research - Cincinnati

    Cincinnati, Ohio, 45219, United States

  • Velocity Clinical Research - Grand Island

    Grand Island, Nebraska, 68803, United States

  • Velocity Clinical Research - Lafayette - PPDS

    Lafayette, Louisiana, 70508-5173, United States

  • Velocity Clinical Research - Lincoln

    Lincoln, Nebraska, 68510, United States

  • Velocity Clinical Research - Norfolk

    Norfolk, Nebraska, 68701, United States

  • Velocity Clinical Research - Omaha

    Omaha, Nebraska, 68134, United States

  • Velocity Clinical Research - Savannah

    Savannah, Georgia, 31406, United States

  • Velocity Clinical Research - Sioux City

    Sioux City, Iowa, 51106, United States

  • Velocity Clinical Research - Vestal

    Vestal, New York, 13850, United States

  • Victoria Clinical Research Group

    Victoria, Texas, 77979, United States

  • iResearch Savannah - CenExel - PPDS

    Savannah, Georgia, 31405, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.