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Could a common blood pressure drug improve major surgery outcomes?

NCT ID NCT05276596

Disease control Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving norepinephrine early during major abdominal surgery could prevent drops in blood pressure and reduce organ problems afterward. 500 adults aged 50 and older took part. One group received norepinephrine early, while the other received the standard drug ephedrine. The main goal was to see if the early norepinephrine group had fewer complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine (noradrenaline)
What this could lead to
If it works, this could point toward a better way to manage blood pressure during major abdominal surgery, potentially reducing complications.
What could go wrong
This is a completed phase 3 trial, but results are not yet widely reported. The benefit over standard care (ephedrine) is unproven, and norepinephrine can have side effects like heart rhythm problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

500 people

The number who actually took part.

Started

Nov 2021

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for major abdominal surgery (defined as surgery with a risk of cardiovascular complications of \>1% and/or lasting more than 2 hours) with general anaesthesia. * American Society of Anesthesiologists physical status (ASA-PS) score of ≥2. * Age of ≥50 years and weighing more than 50 kg * Written informed consent. Exclusion Criteria: * Emergency surgery. * Untreated or uncontrolled hypertension (systolic blood pressure of \>150 mm Hg), despite medication. * Any acute cardiovascular event, including acute or decompensated heart failure or acute coronary syndrome. * Patients with chronic kidney disease with a glomerular filtration rate of \<30 ml.min-1/1.73 m2 or requiring renal replacement therapy for end-stage renal disease. * Patients with severe hepatic failure (ASAT/ALAT of \>2N, elevated bilirubin level, PT of \<50%). * Preoperative sepsis, septic shock. * Preoperative norepinephrine infusion. * Patients eligible for a surgical procedure under locoregional anaesthesia. * Pregnancy. * Known allergy to study treatment. * Patients unable to give informed consent for any reason.

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Conditions

The condition(s) this trial relates to.

hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesiology Hypotension Major abdominal surgery Norepinephrine

Contacts and locations

Locations

  • CHU Amiens

    Amiens, 80480, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.