Could early drug stop debilitating tumors before they start?
NCT ID NCT06188741
Summary
This study is testing if starting a drug called selumetinib early can prevent dangerous tumors from growing and causing serious problems in young children with neurofibromatosis type 1 (NF1). It will enroll 200 children aged 1 to 8 years who have these tumors in high-risk areas but don't yet have symptoms. Researchers will compare children who receive the drug to those who are just observed to see if early treatment improves long-term health.
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Contacts and locations
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Study contacts
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Children's Hospital of Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Childrens of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
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Cincinnati Childrens Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229-, United States
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Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21231, United States
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Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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National Cancer Institute/ National Institutes of Health
RECRUITINGBethesda, Maryland, 20892, United States
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Riley Hospital for Children/Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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University of Chicago
RECRUITINGChicago, Illinois, 63637, United States
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University of Texas, Southwestern
RECRUITINGDallas, Texas, 75390, United States
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Conditions
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