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E-Cig nicotine levels may influence how much smokers puff and switch

NCT ID NCT05887947

Knowledge-focused Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether different nicotine concentrations in e-cigarettes (5% vs 1.8%) change how much smokers puff, how much nicotine they get, and whether they switch completely from cigarettes. Fifty-two Black and white smokers who wanted to switch to e-cigarettes for 6 weeks took part. Researchers measured puffing patterns and smoking status to see if nicotine strength helps people quit smoking.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Electronic cigarette with 5% or 1.8% nicotine concentration (Vuse Alto)
What this could lead to
If it works, this could help design better e-cigarettes to help people switch away from smoking tobacco cigarettes.
What could go wrong
This was a small, completed study with only 52 people, so results may not apply to everyone. E-cigarettes still carry health risks and are not proven safe for quitting smoking.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Feb 2023

Finished

Jun 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. identify as non-Hispanic white or non-Hispanic African American/Black 2. willing to switch from smoking to e-cigarettes for 6 weeks 3. speak and understand English 4. smoke greater than or equal to 25 of the last 30 days for the past 3 months 5. not previously used an e-cigarette for longer than 30 days 6. exhaled carbon monoxide of greater than or equal to 6ppm at screener visit 7. willing to abstain from marijuana for 12 hours prior to in-person lab visits 8. willing to abstain from smoking and vaping for 12 hours prior to 3 in-person lab visits Exclusion Criteria: 1. weekly use of an EC over the last six months 2. use of tobacco products other than cigarettes on greater than or equal to 10 days in the past 30 days 3. use of EC on more than 5 of the past 30 days 4. current use of cessation medications 5. pregnant, planning to become pregnant, or breastfeeding 6. past 30 day hospitalization/ER visit for psychiatric issue, seizure, stroke, or new heart problem 7. recent history of cardiovascular or pulmonary events in the past three months 8. treatment for alcohol or drug dependence in the past year 9. household member currently or previously enrolled in the study 10. current enrollment in a program aimed at changing smoking patterns

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Conditions

The condition(s) this trial relates to.

Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Smoking cessation

Contacts and locations

Locations

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.