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Tiny study probes urea breakdown in dialysis patients

NCT ID NCT05076318

Knowledge-focused Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from Aarhus University looked at how the urea cycle works in 10 people with end-stage kidney disease on dialysis. Participants received a 3-hour alanine infusion, and researchers measured urea production before and after dialysis. The goal was to understand urea cycle dysregulation, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
alanine infusion
What this could lead to
If successful, this could improve understanding of urea cycle problems in kidney failure, potentially guiding better dialysis or dietary management.
What could go wrong
This is a very small, early-stage observational study with only 10 participants, so results may not apply broadly. It is not testing a treatment, only measuring a biological process.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Mar 2022

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> or equal to 18 years * Chronic hemodialysis during 3 months * Patients with functioning arteriovenous-fistula assigned to "Center-Hemodialysis" at "Nyresygdomme, AUH Skejby" Exclusion Criteria: * Active infection * Conditions with vomiting or diarrhea * Diabetes * Active disease being treated with chemotherapy, radiationtherapy, biologic- or similar treatments. Disease under observation can be included. * Liver disease * Vessels on the upper extremities not suited for cannulation * Prednisolone treatment during the last 8 weeks * Pregnancy * BMI \> or equal to 30 or \< or equal to 18 * Physically or mentally condition that does not allow the project to be completed * Language-difficulties that does not allow the project to be completed

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Conditions

The condition(s) this trial relates to.

end stage renal failure urea cycle disorder uremia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urea cycle disorder UREMIA

Contacts and locations

Locations

  • University Hospital Aarhus

    Aarhus N, 8200, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.