New drug DYNE-101 aims to ease muscle stiffness in rare disease
NCT ID NCT05481879
First seen Nov 06, 2025 · Last updated May 24, 2026 · Updated 24 times
Summary
This study tests a new drug, DYNE-101, in 116 adults with myotonic dystrophy type 1 (DM1), a condition that causes muscle weakness and stiffness. The main goal is to see if the drug is safe and tolerable, and to measure its effects on muscle function and disease markers. Participants receive multiple doses of the drug or a placebo over several months, with long-term follow-up.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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CHU de Nantes
RECRUITINGNantes, 44093, France
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Centro Clinico Nemo
RECRUITINGMilan, 20162, Italy
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Charité - Universitätsmedizin Berlin
RECRUITINGBerlin, 10117, Germany
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Fondazione Policlinico Universitario A Gemelli-Rome
RECRUITINGRome, 00168, Italy
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Indiana University School of Medicine
RECRUITINGIndianapolis, Indiana, 46202, United States
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Institut de Myologie
RECRUITINGParis, 75013, France
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John Walton Muscular Dystrophy Research Centre
RECRUITINGNewcastle upon Tyne, United Kingdom
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Ludwig Maximilians University, Munich - Friedrich Baur Institut
RECRUITINGMunich, 80336, Germany
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NZCR Auckland
RECRUITINGAuckland, 1023, New Zealand
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Neurology Rare Disease Center
RECRUITINGDenton, Texas, 76208, United States
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Radboud Medical Center
RECRUITINGNijmegen, Netherlands
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Salford Royal Hospital
RECRUITINGSalford, M6 8HD, United Kingdom
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St. Vincent's Hospital
RECRUITINGFitzroy, Victoria, 3065, Australia
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Stanford University
RECRUITINGStanford, California, 94305, United States
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University College London Hospitals
RECRUITINGLondon, NW1 2BU, United Kingdom
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University of Florida College of Medicine
RECRUITINGGainesville, Florida, 32610, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of Rochester Medical Center
RECRUITINGRochester, New York, 14642, United States
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Virginia Commonwealth University (VCU)
RECRUITINGRichmond, Virginia, 23298, United States
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Washington University in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
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Conditions
Explore the condition pages connected to this study.