Can a depression drug ease knee replacement pain?
NCT ID NCT05086393
First seen Nov 14, 2025 · Last updated Jun 10, 2026 · Updated 25 times
Summary
This study tested whether duloxetine, a medication usually used for depression, can help reduce pain and the need for strong painkillers after knee replacement surgery. 241 adults having knee replacement took part in a triple-blind trial where neither they, their doctors, nor the researchers knew who got the drug or a placebo. The goal was to see if adding duloxetine to standard pain management improves recovery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Rush University medical Center
Chicago, Illinois, 60612, United States
Conditions
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