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Can a pill and patch help dual users kick the smoking habit?

NCT ID NCT06474299

First seen Nov 01, 2025 · Last updated Jun 20, 2026 · Updated 43 times

Summary

This study tests whether a combination of varenicline (a pill) and nicotine patches can help people who both smoke cigarettes and use e-cigarettes quit smoking. About 500 participants will take the medications and be followed for 12 months to see if they stay smoke-free. The goal is to find the most effective approach for this group.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • University of Wisconsin-Madison School of Medicine and Public Health

    RECRUITING

    Madison, Wisconsin, 53792, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

varenicline and nicotine patches

What this could lead to

If successful, this could identify the best combination of medications to help dual users quit smoking, reducing their health risks.

What could go wrong

This is a Phase 4 screening trial, so results are preliminary. The interventions may not work for everyone, and side effects like nausea or skin irritation are possible.

Conditions

The condition(s) this trial relates to.

Smoking Cessation Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.