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Could a common antibiotic ease tennis elbow pain?

NCT ID NCT04686799

Symptom relief Sponsor: Hospital for Special Surgery, New York Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tested whether a low, non-antibiotic dose of doxycycline could help people with tennis elbow (elbow tendinopathy). The goal was to see if patients would take the medication as prescribed and if it might reduce pain and improve function. Twenty-one adults with elbow pain lasting at least 6 weeks took doxycycline twice daily for 12 weeks, and researchers tracked their compliance and symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
doxycycline (low dose)
What this could lead to
If this approach works, it could offer a new, non-surgical way to manage tennis elbow pain by targeting inflammation.
What could go wrong
This is a very early, small feasibility study with only 21 participants. It does not prove that doxycycline is effective for tennis elbow, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

21 people

The number who actually took part.

Started

Dec 2020

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males and females ages of 18 and up * Atraumatic unilateral elbow pain of ≥ 6 weeks duration * Diagnosed clinically as lateral or medial elbow tendinopathy * Activity-related lateral or medial elbow pain * Tenderness of the lateral or medial epicondyle * Pain with gripping and/or resisted wrist extension with the elbow extended * Pain with passive wrist flexion and finger with the elbow extended * Internet access to complete electronic surveys Exclusion Criteria: * Prior surgery of the affected elbow * Prior injection of the affected lateral or medial epicondyle or extensor tendons * Prior extracorporeal shockwave therapy to the affected elbow * Suspicion for radial tunnel syndrome (tenderness distal to the lateral epicondyle in the area of the supinator muscle dorsally, pain with resisted supination with the elbow extended, and/or weakness of the extensor digitorum communis) * Separate upper extremity injury or condition that would interfere with full participation in the home exercise program * Fluoroquinolone-associated tendinopathy * Ligamentous laxity on exam * Evidence of osteoarthritis or osteochondral lesion on radiographs * Autoimmune condition * Pregnant, intend to become pregnant, or breastfeeding * Premenopausal women who are not using contraception * Allergy to doxycycline or other tetracyclines * Current esophagitis or peptic ulcer disease * Current use of medication for which there is a drug interaction with doxycycline * Who do not speak English

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Conditions

The condition(s) this trial relates to.

Elbow Tendinopathy epicondylitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lateral epicondylitis Lateral epicondylitis (tennis elbow) bilateral Lateral epicondylitis, left elbow Lateral epicondylitis, right elbow Lateral epicondylitis, unspecified elbow Medial epicondylitis Medial epicondylitis, left elbow Medial epicondylitis, right elbow

Contacts and locations

Locations

  • Hospital for Special Surgery

    New York, New York, 10021, United States

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