Could a common antibiotic ease tennis elbow pain?
NCT ID NCT04686799
First seen Jan 05, 2026 · Last updated Jun 19, 2026 · Updated 31 times
Summary
This early study tested whether a low, non-antibiotic dose of doxycycline could help people with tennis elbow (elbow tendinopathy). The goal was to see if patients would take the medication as prescribed and if it might reduce pain and improve function. Twenty-one adults with elbow pain lasting at least 6 weeks took doxycycline twice daily for 12 weeks, and researchers tracked their compliance and symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Hospital for Special Surgery
New York, New York, 10021, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline (low dose)
What this could lead to
If this approach works, it could offer a new, non-surgical way to manage tennis elbow pain by targeting inflammation.
What could go wrong
This is a very early, small feasibility study with only 21 participants. It does not prove that doxycycline is effective for tennis elbow, and results may not apply to everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.