Could a common antibiotic ease tennis elbow pain?

NCT ID NCT04686799

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early study tested whether a low, non-antibiotic dose of doxycycline could help people with tennis elbow (elbow tendinopathy). The goal was to see if patients would take the medication as prescribed and if it might reduce pain and improve function. Twenty-one adults with elbow pain lasting at least 6 weeks took doxycycline twice daily for 12 weeks, and researchers tracked their compliance and symptoms.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
doxycycline (low dose)
What this could lead to
If this approach works, it could offer a new, non-surgical way to manage tennis elbow pain by targeting inflammation.
What could go wrong
This is a very early, small feasibility study with only 21 participants. It does not prove that doxycycline is effective for tennis elbow, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Elbow Tendinopathy epicondylitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Hospital for Special Surgery

    New York, New York, 10021, United States

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