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Can a common antibiotic prevent STIs? new study tests two dosing strategies

NCT ID NCT06188442

Prevention Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking doxycycline before potential exposure to STIs works better than taking it after exposure. 300 men who have sex with men will be randomly assigned to one of two groups and followed for 2 years. The goal is to see which approach better prevents chlamydia, gonorrhea, and syphilis, and whether both are safe and acceptable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * has had sex with another male in the past six months * normally reside in Hong Kong * can communicate in written and spoken Chinese or English * willing and able to give written informed consent * being willing and able to attend scheduled study clinic visits * at risk of STI (had condomless sex with more than one man in the past 12 months, history of STI diagnosis in the past 12 months, inclination to have condomless sex, and other HIV-PrEP-eligible criteria) Exclusion Criteria: * Being allergic to tetracycline class medicines * Currently taking medications that are contraindicated with doxycycline * Using antibiotics for more than 14 days in the month preceding enrolment

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Conditions

The condition(s) this trial relates to.

bacterial sexually transmitted disease chlamydia infectious disease Homosexuality sexually transmitted disease chlamydia trachomatis infectious disease prevention target gonorrhea prevention target syphilis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chlamydia Gonorrhea Sexually transmitted diseases, bacterial Syphilis

Contacts and locations

Locations

  • Stanley Ho Centre for Emerging Infectious Diseases

    Shatin, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.