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Dopamine boost shows promise for depression in seniors

NCT ID NCT04469959

First seen Feb 06, 2026 · Last updated May 01, 2026 · Updated 14 times

Summary

This study looks at whether a drug called levodopa (L-DOPA), which increases dopamine in the brain, can improve mood, thinking speed, and walking in older adults with depression. About 100 people aged 60 and older with depression and slowed thinking or walking will take part. The goal is to see if boosting dopamine can ease depression symptoms and improve daily function.

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Contacts and locations

Locations

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

  • Vanderbilt Psychiatric Hospital

    Nashville, Tennessee, 37212, United States

Conditions

Explore the condition pages connected to this study.