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Can a heart drug save kidneys in septic shock surgery?

NCT ID NCT06462313

Disease control Sponsor: First Affiliated Hospital of Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether the drug dobutamine helps people with septic shock who are having surgery. Septic shock is a life-threatening condition where blood pressure drops dangerously low. The researchers wanted to see if dobutamine could reduce kidney injury, organ failure, and death. The study included 584 adults and compared outcomes after surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

584 people

The number who actually took part.

Started

Jun 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with 18 years or older 2. Sugery patients with septic shock and the duration of opration is more than 1 hour Exclusion Criteria: 1. Pregnancy; 2. Long-term intakeβ-receptor blocker; 3. patietns with dobutamine used within 72h before enrollment; 4. Patients use Recombinant Human Brain Natriuretic Peptide(rhBNP), Levosimendan and Epinephrine within 72h before enrollment; 5. Patients with hyperthyroidism; 6. Allergy or known sensitivity to catecholamines（norepinephrine, dobutamine etc.）and genera anesthetics. 7. Patients and guardians refused to participate in this intervention clinical trial.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

General anesthesia Patients with septic shock Surgical patients

Contacts and locations

Locations

  • The First Affiliated Hospital, School of Medicine, Zhejiang University

    Hangzhou, Zhejiang, 310000, China

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