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New app aims to take the guesswork out of water pill dosing

NCT ID NCT04759274

Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests a mobile app that helps people with kidney problems adjust their water pill (diuretic) doses day by day to control swelling. Thirty participants will use the app for 90 days, entering daily weight and blood pressure readings. The goal is to see if the app helps them reach and maintain a healthy fluid balance more quickly and safely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Diuretic Tuner mobile application
What this could lead to
If it works, this app could help people with kidney disease manage fluid buildup more easily at home, reducing hospital visits.
What could go wrong
This is a small, early study with only 30 people. The app may not work for everyone, and daily self-monitoring can be burdensome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2023

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The presence of nephrotic range proteinuria (\> 3 g/d proteinuria by 24hr urine protein, 24hr urine albumin, spot urine protein/creatinine ratio, or spot urine albumin/creatinine ratio) or stage 4 or 5 chronic kidney disease (estimated glomerular filtration rate \< 30 mL/min/1.73 m2 by Modification of Diet in Renal Disease equation) PLUS * Clinical signs of hypervolemia present (lower extremity edema, ascites, or pleural effusions) with an estimated dry weight (defined as edema-free weight without orthostatic hypotension) 5 lbs less than enrollment body weight Exclusion Criteria: * Weight \< 100 lbs or \> 300 lbs. * Autonomic insufficiency resulting in orthostatic hypotension at screening * Hypokalemia at enrollment (defined as serum potassium \< 3.5 mmol/L) * Moderate to severe hyponatremia at enrollment (defined as serum sodium \< 130 mmol/L) * Serum creatinine \> 6 mg/dL or \> 1.5 times baseline * Patients who are unable or unwilling to measure their home blood pressures and weights * Patients without a working phone number and smart phone device * Expectation that the patient will require dialysis initiation within \< 3 months * Expected lifespan of \< 6 months * The presence of a medical condition that would interfere with effectively using the Diuretic Tuner (dementia, illiteracy, or blindness) * Pregnant patients * Prisoners

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome Edema end stage renal failure nephrotic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney diseases Edema Hypervolemia Nephrotic syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Texas Southwestern

    RECRUITING

    Dallas, Texas, 75390, United States

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