Can a special diet help PSC patients? small study tests two options

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Males and females between 18 and 70 years of age, inclusive based on the date of the screening visit 2. Willing and able to give informed consent prior to any study specific procedures being performed 3. Diagnosis of PSC documented by typical cholangiogram findings with no evidence of a secondary cause of sclerosing cholangitis 4. Serum alkaline phosphatase greater than 1.5 times the upper limit of the normal (ULN) reference range 5. Simple clinical colitis activity index \< 5 6. For subjects on UDCA, the dose of UDCA must have been stable for at least 3 months before screening. For subjects not on UDCA, no UDCA use for at least 3 months before screening. 7. Platelet count \> 150,000/mm3 8. Albumin \> 3.3 g/dL 9. Serum creatinine \< ULN 10. Willing and able to comply with scheduled visits, laboratory tests, stool collection, and other study procedures including to follow a vegan/low-sulfur diet or SCD for the duration of the trial regardless of treatment arm randomization 11. Able to read English and complete PSC PRO independently Exclusion Criteria: 1. Pregnant or lactating females 2. ALT \> 10 x ULN 3. Total bilirubin \> 2 X ULN 4. INR \> 1.2 5. Decompensated cirrhosis defined by ascites, hepatic encephalopathy, or variceal bleeding 6. Small duct PSC 7. Other causes of liver disease including secondary sclerosing cholangitis, viral, metabolic, alcoholic, and other autoimmune liver diseases. Subjects with non-alcoholic fatty liver disease may be included if there is no evidence of NASH in the opinion of the investigator 8. Positive AMA 9. History of liver transplantation 10. History of hepatocellular carcinoma or cholangiocarcinoma 11. Ascending cholangitis within 90 days of enrollment 12. Any antibiotic use within 90 days of enrollment or planned antibiotic use during the study period 13. Current vegetarian or adherence to the SCD 14. Nut allergy (Many of the recipes included in the specific carbohydrate diet substitute nut flour for wheat flour. Subjects randomized to either the specific carbohydrate diet arm will have difficulty with dietary adherence as they will be intolerant of this dietary staple). 15. Inability to complete dietary log. 16. History of malignancy within 5 years except for adequately treated carcinoma in situ of the cervix and basal or squamous cell carcinoma. 17. Concurrent participation in another therapeutic clinical trial 18. Celiac disease 19. Any laboratory abnormality or condition which in the opinion of the investigator could adversely affect the safety of the participant or impair the assessment of the study results