Could your diet reshape your gut bacteria? new study investigates

NCT ID NCT07672691

Knowledge-focused Sponsor: The Jerzy Kukuczka Academy of Physical Education in Katowice Source: ClinicalTrials.gov ↗

First seen Jun 29, 2026 · Last updated Jul 02, 2026 · Updated 3 times

Summary

This study compares the effects of a ketogenic diet (high fat, very low carb) and a vegetarian diet (plant-based) against a standard mixed diet on gut bacteria, inflammation, and blood markers. Over 12 weeks, 200 adults aged 18-60 will provide stool and blood samples to track changes. The goal is to understand how different eating patterns influence gut health and metabolism.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: ketogenic diet and vegetarian diet
What this could lead to: If successful, this could help tailor dietary recommendations for improving gut health and metabolic function.
What could go wrong: This is an early-stage dietary study with no direct treatment goal; results may not apply to everyone and adherence to strict diets can be challenging.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: In addition to the physical activity requirements described above, the study will include men and women aged 18-60 years with: BMI not exceeding 40kg/m² Habitual mixed diet prior to study enrollment Normal blood pressure * Exclusion Criteria: Poprawiłem już \*\*Exclusion Criteria\*\* w poprzedniej odpowiedzi - wszystkie te kryteria już tam są wpisane. Oto pełna, ostateczna wersja z wszystkimi wskazanymi kryteriami wyłączenia: \*\*\* \*\*Exclusion Criteria:\*\* * Use of medications regulating \*\*glucose levels\*\* (e.g., metformin) or \*\*blood lipids\*\* (e.g., \*\*statins\*\*) * \*\*Hypertension\*\* or pharmacological treatment for hypertension * Diagnosed \*\*gastrointestinal disorders\*\*, including: * Gastric and duodenal ulcers * \*\*Irritable bowel syndrome (IBS)\*\* * \*\*Ulcerative colitis\*\* * \*\*Celiac disease\*\* * Chronic use of medications such as: * \*\*Mesalazine\*\* * \*\*Corticosteroids\*\* * \*\*Statins\*\* * \*\*Proton pump inhibitors (PPI)\*\* * \*\*Non-steroidal anti-inflammatory drugs (NSAIDs)\*\* * \*\*Anticonceptional medications\*\* * \*\*Any supplements\*\* * \*\*Alcohol consumption\*\* \> 2 times/week with \> 15 g alcohol per occasion (approximately 15 g alcohol = 330 mL beer, 150 mL dry red wine, or 50 mL vodka) * \*\*Smoking cigarettes\*\* * Following a \*\*ketogenic diet\*\* or \*\*vegetarian diet\*\* within \*\*1 month\*\* prior to study enrollment

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Conditions

The condition(s) this trial relates to.

nutritional disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIET Gene expression Ketogenic diet Nutrition

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could your diet reshape your gut bacteria? new study investigates

What the study statuses mean