Can diet help manage a rare muscle disease? new study seeks answers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (Adults with IBM): * Diagnosis of Inclusion Body Myositis: As defined by the revised European Neuromuscular Centre 2013 diagnostic criteria (Definite or Probable IBM) * Age: Adults aged ≥40 years at the time of consent. * Ability to Provide Informed Consent: Participants must be cognitively capable of providing written, informed consent. * Disease Progression: Participants must be able to walk short distances, with or without the use of an assistive aid (e.g., a cane or frame) for balance, so that they can undertake study procedures without safety concerns. Must be able to consume solid or modified-texture food, with or without dysphagia adaptations (i.e., not exclusively tube-fed). * Willingness to Participate: Willing to attend study visits and comply with all study procedures. Inclusion Criteria (Control Participants): * Disease-Free: Control participants must be generally healthy, with no known myopathies or metabolic diseases. They must not have any conditions that, in the judgement of a clinician, would compromise their safety, impair their ability to complete study procedures, or influence study outcomes. * Age: Adults aged ≥40 years at the time of consent. * Ability to Provide Written Informed Consent * Willingness to Participate * Matched to IBM participants according to their age and physical activity levels Exclusion Criteria (Adults with IBM): * Coexisting Neuromuscular or Metabolic Disorders: Presence of other neuromuscular or metabolic disorders that may confound the outcomes of interest. * Severe Dysphagia: Participants requiring exclusive enteral or parenteral feeding, which would prevent participation in dietary intake assessments. * Enrolment in an interventional trial within the past 3 months: Participation in an interventional study within the past 3 months involving interventions that may affect dietary habits, physical activity, or muscle metabolism. * Contraindications to any Study Procedures: Any condition preventing safe completion of key assessments. For instance: severe osteoporosis contraindicating DXA scanning (T-score \< -3.0), respiratory conditions, severe claustrophobia, severe cognitive impairments or communication barriers that may impair participant ability to comply with study procedures. * Logistical Concerns: Any other logistical concern, as judged by the CI, that would compromise participant safety or the integrity of study data. * English Comprehension: Participants will be excluded if they are unable to understand written or verbal English to a degree that would impair their ability to provide informed consent or fully understand the study procedures. Exclusion Criteria (Control Participants): * Diagnosed neuromuscular or metabolic Disorder * Enrolment in an interventional trial within the past 3 months * Contraindications to any study procedures such as those listed for IBM participants (e.g., DXA, MRI). * Logistical or safety concerns, as judged by the research team. * To minimise dietary overlap, individuals living in the same household as an IBM participant will not be eligible. * Do not meet the physical activity criteria to be appropriately matched to an IBM participant * Unable to understand written or verbal English