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New program aims to cut unnecessary antibiotics in ventilated kids

NCT ID NCT04987840

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a diagnostic stewardship program—a set of guidelines to help doctors decide when to order respiratory cultures—can safely reduce antibiotic use in critically ill children on ventilators. Researchers will track changes in how often cultures are taken and how many antibiotics are prescribed across 15 children's hospitals. The goal is to find a way to lower antibiotic overuse without harming patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could provide hospitals with a proven strategy to reduce unnecessary antibiotic use in children on ventilators, lowering the risk of antibiotic resistance.
What could go wrong
This is a very small, early-stage implementation study with only 15 hospitals. It focuses on changing doctor behavior, not testing a new drug, so results may not apply broadly or lead to immediate patient benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2021

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

ICU patient populations from units that develop and implement a quality improvement program to reduce respiratory culture use

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Institutions that plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs Exclusion Criteria: * Institutions that do not plan to develop and implement a quality improvement program to reduce respiratory culture use in their Pediatric ICUs

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated tracheobronchitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tracheobronchitis Ventilator associated pneumonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    8 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

  • Children's Hospital and Medical Center Omaha

    Omaha, Nebraska, 68114, United States

  • Children's Minnesota Hospital

    Minneapolis, Minnesota, 55404, United States

  • Cleveland Clinic Children's Hospital

    Cleveland, Ohio, 44106, United States

  • Dell Children's Medical Center

    Austin, Texas, 78723, United States

  • Johns Hopkins Children's Center

    Baltimore, Maryland, 21287, United States

  • Le Bonheur Children's Hospital

    Memphis, Tennessee, 38103, United States

  • Monroe Carell Jr. Children's Hospital

    Nashville, Tennessee, 37232, United States

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